Derivatives of bicyclic aminoacids, processes for their...

C - Chemistry – Metallurgy – 07 – D

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530/5.06, 260/20

C07D 209/42 (2006.01) C07D 403/06 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1223868

- 1 - HOE 82/F 054 Abstract of the disclosure: The invention relates to compounds of the formula I (I) Image in which n denotes 0 or 1, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cyclo- alkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be sub- stituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes - 2 - HOE 82/F 054 hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylene- dioxy or 3-indolyl, and their physiologically acceptable salts, pro- cesses for their preparation, agents containing these and their use as medicaments and also bicyclic amino acids as their intermediates and processes for their preparation.

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