Derivatives of clavulanic acid, their preparation and use

Details Derivatives of clavulanic acid, their preparation and use Derivatives of clavulanic acid, their preparation and use

C - Chemistry, Metallurgy

07

D

260/299

C07D 498/04 (2006.01) C07D 503/00 (2006.01)

Patent

CA 1117532

ABSTRACT OF THE DISCLOSURE Compounds of the formula (I) are disclosed Image wherein R is a hydrogen atom or a methyl, methoxyl, hydroxymethyl, or nitrile group; R1 is a hydrogen atom or a lower alkyl, aralkyl, phenyl or inertly substituted lower alkyl, aralkyl or phenyl group; R2 is a hydrogen atom or a lower alkyl, aralkyl, phenyl or inertly substituted lower alkyl, aralkyl or phenyl group; and R3 is lower alkyl, aralkyl, phenyl or inertly substituted lower alkyl, aralkyl or phenyl group; any of said groups R1, R2 and R3 being optionally interlinked to form a ring of 5 - 7 ring atoms. Methods of preparation are also disclosed. The novel salts are useful in enhancing the effectiveness of penicillins and cephalosporins and have improved storage properties.

315415

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