Derivatives of cycloalka[c]pyrrolcarboxylic acids, a process...

Details Derivatives of cycloalka[c]pyrrolcarboxylic acids, a process... Derivatives of cycloalka[c]pyrrolcarboxylic acids, a process...

C - Chemistry, Metallurgy

07

D

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C07D 209/44 (2006.01) C07D 209/52 (2006.01) C07D 217/24 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1198118

- 63 - Abstract of the disclosure: Compounds of the formula I Image (I) in which n = 1, 2 or 3, R1 = hydrogen, optionally amino-, acylamino or benzoylamino-substituted by alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partly hydro- genated aryl, either of which can be substituted by alkyl, alkoxy or halogen, arylalkyl which can be substituted in the aryl radical as defined above, a monocyclic or bicyclic heterocyclic radical having up to 10 ring atoms of which 1 to 2 ring atoms represent sulfur or oxygen atoms, and/or of which 1 to 4 ring atoms represent nitrogen atoms, or an aminoacid side chain, R2 = hydrogen, alkyl, alkcenyl or arylalkyl, Y = hydrogen or hydroxyl, - 64 - Z = hydrogen or Y and Z together = oxygen and X = alkyl, alkenyl, cycloalkyl, aryl which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol- 3-yl, a process for their preparation, agents containing these compounds, their use, and intermediates and a process for their preparation. Compounds of the Formula I, and their salts, can be used to control hypertension of various etiologies .

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