Derivatives of cyclosporine a, antibodies directed thereto...

Details Derivatives of cyclosporine a, antibodies directed thereto... Derivatives of cyclosporine a, antibodies directed thereto...

C - Chemistry, Metallurgy

12

P

167/103, 167/44,

C12P 21/08 (2006.01) A61K 38/13 (2006.01) A61K 47/48 (2006.01) C07K 7/64 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 33/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2004626

NOVEL DERIVATIVES OF CYCLOSPORINE A, ANTIBODIES DIRECT- ED THERETO AND USES THEREOF Abstract of the Disclosure This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reac- tive group. This invention also provides a composi- tion of matter which comprises a conjugate of a com- pound and the aforementioned molecule wherein the com- pound is bound to the molecule through the reactive group. This invention further provides an antibody directed to the aforementioned composition of matter specific for cyclosporine A or congener of cyclosporine A. Finally, this invention provides a method of moni- toring levels of cyclosporine A or congener of cyclosporine A in a subject.

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