Derivatives of diphenylhydantoin, pharmaceutical...

A - Human Necessities – 61 – K

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A61K 31/415 (2006.01) C07D 233/74 (2006.01)

Patent

CA 1139672

Institut National des Radioéléments - Nationaal Instituut voor Radio-Elementen, en Abrégé : "I.R.E." "Derivatives of diphenylhydantoin, pharmaceutical composi- tions comprising such derivatives and process of prepara- tion" ABSTRACT Psychotropic composition comprising as an ac- tive constituent, a pharmaceutical composition, more parti- cularly a psychotropic composition, characterised in that it comprises as an active constituent, a deuterated phenylhy- dantoin corresponding to the general formula Image wherein radicals R1 are identical or different and represent hydrogen or methyl, R2 is ethyl or a substituted or unsubs- tituted phenyl group, which is deuterated or not, R3 is hy- drogen, halogen or a linear or ramified alkyl radical com- prising 1 to 4 carbon atoms, a linear or ramified alkoxy ra- dical comprising 1 to 4 carbon atoms, a trifluoromethyl, hy- droxy, nitro or amino radical, X is an oxo, thio or methy- lene groupe and x is an integer of 1-5, one of its enantio- ners or one of its salts with a physiologically acceptable base, in combination with a pharmaceutically acceptable ve- hicle.

346003

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