Derivatives of doxorubicine, their preparation and use

C - Chemistry – Metallurgy – 07 – H

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260/208.2

C07H 15/24 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1115694

ABSTRACT OF THE DISCLOSURE New derivatives of doxorubicine of the formula (I) Image wherein R represents a radical of the formula Image (II) wherein R1 represents hydrogen, alkyl (possibly substituted with amino, alkylamino, dialkylamino, hydroxy, mercapto or methylthio), phenyl, benzyl (possibly substituted with one or more hydroxy) and R2 represents hydrogen or forms with R1 an alkylene radical, the salts thereof and pharmaceutical compositions containing said compounds. These compounds and their salts possess interesting antitumoral properties together with low toxicity.

332572

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