Derivatives of eburnamomine and related method of manufacturing

Details Derivatives of eburnamomine and related method of manufacturing Derivatives of eburnamomine and related method of manufacturing

C - Chemistry, Metallurgy

07

H

260/228, 260/272

C07H 11/04 (2006.01) C07C 53/128 (2006.01) C07C 59/68 (2006.01) C07C 65/03 (2006.01) C07C 65/05 (2006.01) C07C 65/11 (2006.01) C07D 453/00 (2006.01) C07D 461/00 (2006.01)

Patent

CA 1117939

Abstract The invention relates to a group of compounds having therapeuti- cal activity at the cerebrovascular level, more particularly having vasodilating activity comprising derivatives of eburnamonine having the general formula : Image wherein X is the radical of an acid of the group comprising glucose- -1-phosphate acid, acetylsalicylic acid, pamoic acid, 2,4-dihydro xybenzoic acid, 3,5-dihydroxybenzoic acid pivalic acid and clofibric acid. The process of the invention comprise reacting a suspension or so- lution of the eburnamonine, depending on the desired derivative, in a stechiometrical ratio andat a temperature controlled by the boiling point of the reaction solvent, with the acid, preferably in form of a solution and under stirring until be reaction is completed, the reaction product being thereafter separated.

321006

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