Derivatives of ethanolamine, their preparation, and the...

C - Chemistry – Metallurgy – 07 – C

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C07C 233/51 (2006.01) A61K 31/24 (2006.01) C07C 235/34 (2006.01)

Patent

CA 2083475

Novel derivatives of ethanolamine benzoate that can be used as medication and having the formula: Image wherein R represents : a) either a radical of the formula: Image wherein: - R' represents a hydrogen atom or alkyl radical containing 1 to 5 carbon atoms in a straight or branched chain, - R1 et R2, identical or different, each represent a hydrogen atom or alkyl or alkoxy radical each having 1 to 5 carbon atoms in a straight or branched chain, and - m and n, identical or different, each represent 1, 2 or 3; b) or a fluorenyl radical having the formula: Image in racemic and enantiomeric forms. These novel derivatives and their physiologically tolerable salts can be used in therapeutic applications, specifically for the treatment of Syndrome X, characterized by glucose intolerance, hyperinsulinemia, dyslipemia and hypertension, and for the treatment of hypertension in subjects who are insulin resistant or have one or more metabolic abnormalities.

Nouveaux dérivés de benzoate d'éthanolamine, utilisables comme médicaments et répondant à la formule : Image dans laquelle R représente : a) soit un radical de formule : Image dans laquelle : - R' represente un atome d'hydrogène ou un radical alkyle contenant de 1 à 5 atomes de carbone en chaine droite ou ramifiée, - R1 et R2, identiques ou différents, représentent chacun un atome d'hydrogène ou un radical alkyle ou alkoxy ayant chacun de 1 à 5 atomes de carbone en chaine droite ou ramifiée, et - m et n, identiques ou différents, représentent chacun 1, 2 ou 3 ; b) soit un radical fluorényle de formule : Image sous formes racémiques et énantiomères. Ces nouveaux dérivés et leurs sels physiologiquement tolérables peuvent être utilisés en thérapeutique, notamment pour le traitement du syndrome X, associant intolérance au glucose, hyperinsulinémie, dyslipémie et hypertension, et pour le traitement de l'hypertension chez les sujets insulinorésistants ou ayant une ou plusieurs anomalies métaboliques.

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