Derivatives of etoposide and analogs, and pharmaceutical...

Details Derivatives of etoposide and analogs, and pharmaceutical... Derivatives of etoposide and analogs, and pharmaceutical...

C - Chemistry, Metallurgy

07

H

C07H 17/04 (2006.01) A61K 31/7048 (2006.01) A61P 35/00 (2006.01) C07H 7/033 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2464311

The invention relates to compounds having the following formula (I), in which: Ra represents a sugar moiety, an arylamino group, or an alkyl group comprising at least one amino group, Rb represents an halogen atom, an halogenoalkyl group, a nitro group, or a group -NR(COR') in which R and R', independently from each other, represent an alkyl group, R1 represents H, or a protecting group for COOH group, R2, R3, and R4, independently from each other, represent H, or a protecting group for OH group. The invention also relates to the use of such compounds in pharmaceutical compositions for the treatment of cancers.

L'invention concerne des composés représentés par la formule (I). Dans cette formule, R¿a? représente une fraction sucre, un groupe arylamino, ou un groupe alkyle comprenant au moins un groupe amino; R¿b? représente un atome d'halogène, un groupe halogénoalkyle, un groupe nitro, ou un groupe -NR(COR') dans lequel R et R' représentent indépendamment l'un de l'autre un groupe alkyle, R¿1? représentant H ou un groupe de protection pour le groupe COOH, R¿2? et R¿3?, et R¿4? représentant indépendamment l'un de l'autre H ou un groupe de protection pour le groupe OH. L'invention concerne également l'utilisation de ces composés dans des compositions pharmaceutiques permettant de traiter les cancers.

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