C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/278.2, 260/2
C07D 405/04 (2006.01) C07D 213/57 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 1224467
22 ABSTRACT The present invention relates to the products of general formula: Image (I) in which: . R represents a straight or branched alkyl group having from 2 to 5 atoms of carbon, or the group Image represents a morpholino or piperidino group possibly substituted by I or 2 methyl groups; . n = 2 or 3; . R1 and R2 considered independently each represent hydrogen or a lower alkyl group (1 to 4 carbon atoms) or R1 and R2 taken together represent a (CH2)m group where m = 4 or 5, R3 being equal to H or R1 is H and R2 and R3 considered together represent (CH2)p where p is 3 or 4 . the butyrolactone cycle substitutes the pyridyl group in 2', 3' or 4' position, the salts, isomers and mixtures of isomers of said products; and to a process for preparing said products and to the drugs containing same. The compounds are useful in human therapeutics as protector of the myocardium for correcting disorders of the ventricular rhythm of ischemic origin.
440588
Bernhart Claude
Cautreels Werner
Gautier Patrick
Sanofi
Sim & Mcburney
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