Derivatives of glutamic acid and aspartic acid having...

Details Derivatives of glutamic acid and aspartic acid having... Derivatives of glutamic acid and aspartic acid having...

C - Chemistry, Metallurgy

07

C

167/211, 167/259

C07C 233/83 (2006.01) A61K 31/195 (2006.01) C07C 255/60 (2006.01) C07D 295/185 (2006.01) C07D 307/66 (2006.01) C07D 309/32 (2006.01)

Patent

CA 1325633

ABSTRACT New derivatives of D,L-glutamic acid and D,L-aspartic acid are described having the formulae: Image (IA) Image (IB) in whichn is equal to 1 or 2, R1 is a phenyl group mono-, di- or tri- substituted with linear or branched C1-C4 alkyl groups, which may be the same or different, or with halogens, with a cyano group or a trifluoromethyl group, and in which R2 is selected from the group consisting of morpholino, piperidino and amino with one or two linear, branched or cyclic alkyl group substit- uents containing from 1 to 8 carbon atoms, which may be the same or different, or a pharmaceutically- acceptable salt thereof. The compounds have an antagonistic activity towards bioactive polypeptides and are useful particularly in the treatment of illnesses of the digestive system and the central nervous system, as pain killers, and for the treatment of anorexia and all those affections (for example tumours) in which exogenous or endogenous bioactive polypeptides are involved.

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