Derivatives of glycinamide, their preparation and their use

Details Derivatives of glycinamide, their preparation and their use Derivatives of glycinamide, their preparation and their use

C - Chemistry, Metallurgy

07

C

260/468, 260/525

C07C 271/22 (2006.01)

Patent

CA 1184567

ABSTRACT OF THE DISCLOSURE A glycinamide derivative of the general formu]a I : Image (I) wherein : R is a linear or ramified a]kyl group C5-C18, a linear or ramified alkenyl group C5, C6, C7, C8, C9, C10, C11, C12, C13, C14, C15, C16, C17 or C18, a linear or ramified alkynyl group C4-C10, a linear or ramified acyl group C4-C18, a linear or ramified alkyl group C1-C10, substituted by a phenoxy group, by a hydroxy radical, by an acetoxy radical, by a carboxy radical, by a linear or ramified alkoxycarbonyl group C1-C4, by a carbonyl radical, by a carboxaldehyde group, by an acetal or cetal group, by one or more phenyl groups, by one or more phenyl groups substituted by a halogen atom such as f1uorine, chlorineor bromine, R1 represents hydrogen, a linear or ramified alkyl group C1, C2, C3, C4, C5, C6, C7, C8, C9 or C10, a linear or ramified acyl group C1-C6, a benzoyl group, a linear or ramified alkoxycarbonyl group C1,C2, C3, C4, C5, C6, C7, or C8, a carboxamidomethyl group, R2 represents hydrogen, a linear or ramified alkyl C1, C2, C3, a phenyl group, R3 represents hydrogen, a linear or ramified alkyl group C1, C2, C3, C4, C5, C6, C7 or C8, a phenyl group, optionally substituted by a halogen atom, such as fluorine, chlorine or bromine. R4 represents hydrogen, a linear or ramified alkyl group C1,C2, C3, C4, C5, C6 C7 or C9 as well as salts of these derivatives with non toxic and pharmaceutically usable acids. Such compounds are useful in the treatment of epilepsy and dyskinesiae.

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