Derivatives of guanine

Details Derivatives of guanine Derivatives of guanine

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/18 (2006.01) A61K 31/52 (2006.01) C07C 43/174 (2006.01) C07C 43/178 (2006.01) C07C 43/315 (2006.01) C07D 473/00 (2006.01)

Patent

CA 1285560

ABSTRACT Antivirally active compounds of the formula Image I wherein A is Image (Aa) or (Ab) Image wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R? is (CH2)pOH, NHCONH2 or COR?, R? is hydrogen, hydroxy or amino, p is 1 to 4, R? and R? are independently selected from hydrogen or (CH2)pOH, with the proviso that at least one of R? or R? is hydrogen; or R? and R? together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; processes for preparation of said compounds, pharmaceutical preparations containing the compounds, methods for treatment of virus infections and the medical use of the compounds.

470490

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