C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/74 (2006.01) A61K 31/395 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) C07C 323/20 (2006.01) C07C 323/62 (2006.01) C07D 213/70 (2006.01) C07D 233/84 (2006.01) C07D 235/24 (2006.01) C07D 235/28 (2006.01) C07D 239/38 (2006.01) C07D 249/12 (2006.01) C07D 263/46 (2006.01) C07D 263/58 (2006.01) C07D 263/60 (2006.01) C07D 413/12 (2006.01) C07D 473/00 (2006.01) C07D 473/08 (2006.01) C07D 473/12 (2006.01) C07D 473/3
Patent
CA 2071690
ABSTRACT The novel derivatives of (hetero)aromatic ethers and thioethers represented by the following general formula I: (HET)Ar-x-CH2-Y-CH2-O-R (I) wherein: (HET)Ar represent a mono-,bi- and tri-cyclic aryl or hetero aryl nucleous possibly substituted, X represents -O- or -S-; Y represents -CO-, a linear or branched polymethylene having 0 to 8 carbon atomswith the proviso that it is not (CH2)n in which 0<n<5 when (HET)Ar represents animidazole ring possibly substituted with methyl and/or nitro and simultaneously X = S, -CH(OR1), in which R1 is hydrogen or an acyl group deriving from an aliphatic, aromatic or heterocyclic carboxylic acid, provided that R1 is not hydrogen when (HET)Ar represents a guanine, adenine or adenosine group, -C=N-R2, in which R2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, -NH2, -NHCONH2, -NHCSNH2; and R represents a phenyl substituted at para position with a carboxylor a (C1-C2O) alkoxycarbonyl group in which the alkoxy group may be linear or branched, are endowed with antihyperlipidemic activity. There are furthermore described the process for their preparation and the pharmaceutical compositions containing them.
Bani Massimo
Fraire Cristina
Olgiati Vincenzo
Vanotti Ermes
Marks & Clerk
Pierrel S.p.a.
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