Derivatives of heteroaryl-alkylcarbamates, preparation...

Details Derivatives of heteroaryl-alkylcarbamates, preparation... Derivatives of heteroaryl-alkylcarbamates, preparation...

C - Chemistry, Metallurgy

07

C

C07C 271/10 (2006.01) C07D 215/04 (2006.01) C07D 233/54 (2006.01) C07D 235/14 (2006.01) C07D 237/08 (2006.01) C07D 263/32 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2554609

The invention relates to a compound having general formula (I), wherein: A is selected from among one or more X, Y and/or Z groups; X represents an optionally-substituted methylene group; Y represents a C¿2?-alkenylene, optionally substituted, or a C¿2?-alkynylene; Z represents a C¿3-7? cycloalkyl group; n represents an integer varying between 1 and 7; R¿1? represents an optionally-substituted heteroaryl or naphthalenyl type group; and R¿7? represents a hydrogen atom or a C¿1-6? alkyl group; R¿8 ?represents a hydrogen atom or a C¿1-6? alkyl, C¿3-7? cycloalkyl, C¿3-7? cycloalkyl-C¿1-3? alkylene group. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate. Said compounds have an inhibitory activity on the FAAH enzyme.

Composé répondant à la formule générale (I):dans laquelle A est choisi parmi un ou plusieurs groupes X, Y et/ou Z ; X représente un groupe méthylène éventuellement substitué ; Y représente un C2-alcènylène éventuellement substitué ou un C2-alcynylène ; Z représente un groupe C3-7~cycloalkyle ; n représente un nombre entier allant de 1 à 7 ; R1 représente un groupe de type naphtalènyle ou hétéroaryle éventuellement substitué ; R7 représente un atome d'hydrogène ou un groupe C1-6-alkyle ; R8représente un atome d'hydrogène ou un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-3-~alkylène ; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat.Ces composés ont une activité inhibitrice sur l~enzyme FAAH.

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