C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.22
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1340834
The present invention relates to the production, by recombinant DNA techniques, of derivatives of basic fibroblast growth factor (bFGF). These derivatives of bFGF can act as antagonists and/or superagonists of the wild type molecule in the angiogenic process. These derivatives, as well as wild type bFGF, may be prepared by the use of strains or E. coli which have been transformed with plasmids carrying nucleotide sequence coding for human and bovine bFGF and their derivatives.
611335
Bergonzoni Laura
Cauet Gilles
Isacchi Antonella
Sarmientos Paolo
Farmitalia Carlo Erba S.r.l.
Fetherstonhaugh & Co.
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