Derivatives of human/bovine basic fibroblast growth factor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

530/13, 195/1.22

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340834

The present invention relates to the production, by recombinant DNA techniques, of derivatives of basic fibroblast growth factor (bFGF). These derivatives of bFGF can act as antagonists and/or superagonists of the wild type molecule in the angiogenic process. These derivatives, as well as wild type bFGF, may be prepared by the use of strains or E. coli which have been transformed with plasmids carrying nucleotide sequence coding for human and bovine bFGF and their derivatives.

611335

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