Derivatives of hydroxyphenylsulfanylbenzoic and...

Details Derivatives of hydroxyphenylsulfanylbenzoic and... Derivatives of hydroxyphenylsulfanylbenzoic and...

C - Chemistry, Metallurgy

07

C

C07C 323/62 (2006.01) A61K 31/19 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 295/08 (2006.01) C07D 295/092 (2006.01)

Patent

CA 2335373

Derivatives of hydroxyphenylsulfanylbenzoic and hydroxyphenylsulfanylarylacetic acids of formula (I), wherein X is H, halogen or NO2 group, a is 0 or 1, and m is 2 to 4 if Z is either 4-acetyl-3-hydroxy-2- propylphenoxy of formula (II) or a piperazinyl residue, or m is 1 if Z is quinolin-2-yl or 6-chloroquinoli-2-yl. Processes for the preparation of these compounds and pharmaceutical compositions including them as active ingredients are also described.

L'invention concerne des dérivés d'acides hydroxyphénylsulfanylbenzoïques et hydroxyphénylsulfanylarylacétiques de formule (I), dans laquelle X représente H, halogène ou un groupe NO¿2?, a est égal à 0 ou 1 et m représente une valeur entre 2 et 4 si Z représente soit un 4-acétyl-3-hydroxy-2-propylphénoxy de formule (II) soit un résidu de pipérazinyle ou m est égal à 1 si Z représente un quinolin-2-yle ou 6-chloroquinoli-2-yle. Font aussi l'objet de cette invention des procédés de préparation de ces composés et les compositions pharmaceutiques contenant ces composés faisant office de principes actifs.

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