C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/280, 260/304
C07D 403/00 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)
Patent
CA 1097350
ABSTRACT OF THE DISCLOSURE Compounds of the formulae (I) and (II) Image Image wherein R1 represents a radical selected from the group consisting of hydro- gen; alkyl containing up to 6 carbon atoms being unsubstituted or substituted by at least one of the groups alkoxy and phenylalkoxy each containing up to 4 carbon atoms in the alkoxy moiety; aryl or aralkyl containing from 1 to 4 carbon atoms in the alkyl moiety, the aryl moieties being unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy, and haloalkyl each containing up to 4 carbon atoms, halogen and nitro; pyridyl; or an alkyl group containing from 1 to 4 carbon atoms sub- stituted by a thienyl, imidazolyl or pyridyl ring; R2 and R3, which are the same or different, each represents a hydrogen atom, alkyl containing up to 4 carbon atoms or aryl being unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy and haloalkyl group each containing up to 4 carbon atoms, halogen and nitro; or taken together R2 and R3 also represent a -CH=CH-CH=CH- group being unsubstituted or substituted by a substituent selected from the group consisting of alkyl, alkoxy and haloalkyl, each containing up to 4 carbon atoms, halogen and nitro; R4 is selected from the group consisting of hydrogen, alkyl, aryl and aralkyl containing up to 4 carbon atoms in each alkyl moiety; and A represents a single bond or alkylene containing from 1 to 6 carbon atoms; with the proviso that when A represents a single bond and simultaneously R2 and R3 taken together represent an unsubsti- tuted -CH=CH-CH=CH- group, then R1 is other than a hydrogen atom or methyl group, and physiologically acceptable salts thereof, a process for their preparation and pharmaceutical composition containing them.
265319
Gebert Ulrich
Musil Josef
Weber Rolf-Ortwin
Fetherstonhaugh & Co.
Hoechst Aktiengesellschaft
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