C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/695 (2006.01) A61P 3/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 7/12 (2006.01)
Patent
CA 2712921
The invention relates to compounds of the general formula (I) in which: G1, G2, G3 et G4 are independent from one another, a C-X group or a nitrogen atom; one of G1, G2, G3 and G4 and at most one of G1, G2, G3 and G4 is a C-X group In which X is a -Si(X1)(X2)(X3) group; n is 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Z1, Z2, Z3, Z4 are independent from one another, a nitrogen atom or a C(R6) group, at least one being a nitrogen atom and at least one being a C(R6) group; Z is cyclic amino or acyclic amino; said compounds can be in the state of a base or an addition salt to an acid, as well as in the hydrate or solvate state. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
L'invention concerne les composés de formule générale (I) dans laquelle G1, G2, G3 et G4 représentent, indépendamment l'un de l'autre, un groupe C-X ou un atome d'azote, l'un des G1, G2, G3 et G4 et au maximum l'un des G1, G2, G3 et G4 représente un groupe C-X où X est un groupe -S1(X1)(X2)(X3), n est égal à 0, 1, 2 ou 3, Y représente un aryle ou un hétéroaryle éventuellement substitué, Z1, Z2, Z3, Z4 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C(R6), l'un au moins correspondant à un atome d'azote et l'un au moins correspondant à un groupe C(R6), Z représente soit une aminé cyclique, soit une aminé acyclique, à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvate Procédé de préparation et application en thérapeutique
Dubois Laurent
Evanno Yannick
Malanda Andre
Robic
Sanofi-Aventis
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