C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
530/5.04, 260/23
C07H 13/06 (2006.01) C07K 5/04 (2006.01) C07K 9/00 (2006.01) C07K 17/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1308711
DERIVATIVES OF MONOPHOSPHORYL LIPID A AND PROCESS FOR PREPARATION ABSTRACT OF THE DISCLOSURE Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials, substrates, and the like, wherein the immunostimulant properties of lipid A are desired.
580545
Myers Kent R.
Ribi Edgar Ernst
Gowling Lafleur Henderson Llp
Ribi Immunochem Research Inc.
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