Derivatives of monosaccharides as cell adhesion inhibitors

C - Chemistry – Metallurgy – 07 – H

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C07H 9/04 (2006.01) A61K 31/70 (2006.01) C07H 13/12 (2006.01)

Patent

CA 2359980

The present application relates to a group of novel substituted pentose and hexose monosaccharide derivatives, not previously disclosed, which exhibit potent anti-cell adhesion and anti-inflammatory activities. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treatment, suppression and prevention of cell adhesion mediated chronic inflammatory disorders are also described.

La présente invention concerne un groupe de nouveaux dérivés de pentose ou d'hexose substitués, non divulgués auparavant, possédant de puissantes activités d'anti-adhésion cellulaire et anti-inflammatoires. L'invention concerne également des procédé de préparation, des compositions pharmaceutiques contenant ces composés et des traitements, ainsi que l'élimination et la prévention de troubles inflammatoires chroniques induits par adhésion cellulaire.

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