C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/12 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2551141
The invention relates to compounds having formula (I), the preparation method thereof and the use of same in therapeutics, wherein: R¿1? represents a (C¿1?-C¿6?)alkyl, a (C¿3?-C¿7?)cycloalkyl which is unsubstituted or is mono- or poly-substituted, a (C¿3?-C¿7?)cycloalkylmethyl which is unsubstituted or is mono- or poly-substituted, a phenyl which is unsubstituted or substituted; a benzyl which is unsubstituted or is mono- or disubstituted, a thienyl which is unsubstituted or substituted; R¿2? represents a hydrogen atom or a (C¿1?-C¿3?)alkyl; R¿3? represents a hydrogen atom or a (C¿1?-C¿5?)alkyl; R¿4?, R¿5?, R¿6?, R¿7?, R¿8? and R¿9? each represent, independently of each other, a hydrogen atom, a halogen atom, a (C¿1?-C¿7?)alkyl, a (C¿1?-C¿5?)alkoxy, a trifluoromethyl radical or a S(O)¿n?Alk group; n represents 0, 1 or 2; and Alk represents a (C¿1?-C¿4?)alkyl. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
La présente invention a pour objet des composés répondant à la formule (I): (voir formule I) dans laquelle: R1 représente un (C1-C6)alkyle; un (C3-C7)cycloalkyle non substitué ou substitué une ou plusieurs fois; un (C3-C7)cycloalkylméthyle non substitué ou substitué une ou plusieurs fois; un phényle non substitué ou substitué; un benzyle non substitué ou mono- ou disubstitué; un thiényle non substitué ou substitué; R2 représente un atome d'hydrogène ou un (C1-C3)alkyle; R3 représente un atome d'hydrogène ou un (C1-C5)alkyle; R4, R5, R6, R7, R8 et R9 représentent chacun indépendamment un atome d'hydrogène, un atome d'halogène, un (C1-C7)alkyle, un (C1-C5)alcoxy, un radical trifluorométhyle ou un groupe S(O)n,Alk; n représente 0, 1 ou 2; Alk représente un (C1-C4)alkyle. Procédé de préparation et application en thérapeutique des dits composés.
Barth Francis
Congy Christian
Martinez Serge
Rinaldi-Carmona Murielle
Kirby Eades Gale Baker
Sanofi-Aventis
LandOfFree
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