C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/28 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2693390
This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crys-talline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperprolif-erative diseases and inflammatory conditions. The invention also concerns methods of making the compunds and compositions described herein.
L'invention concerne des composés N-(arylamino)arylsulfonamide qui sont des inhibiteurs de MEK comprenant des formes polymorphes cristallines présentant un profil de diffraction aux rayons X sur poudre spécifique et/ou un profil de calorimétrie à balayage différentiel spécifique. La présente invention concerne également des compositions pharmaceutiques comprenant les composés et des procédés d'utilisation des composés et des compositions décrits ici, y compris l'utilisation dans le traitement et/ou la prévention du cancer, de maladies hyperprolifératives et d'affections inflammatoires. L'invention concerne également des procédés de préparation des composés et des compositions décrits ici.
Dimock Stuart
Girardet Jean-Luc
Miner Jeffrey N.
Quart Barry
Rowlings Colin Edward
Ardea Biosciences Inc.
Marks & Clerk
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