C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/09 (2006.01) A61K 31/40 (2006.01) C07D 223/04 (2006.01)
Patent
CA 2542727
The invention relates to compounds having general formula (I), wherein: n represents the number 1 or 3; R¿1? represents either H or a cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl group; X represents either H or one or more substituents selected from among halogen atoms and the trifluoromethyl, alkyl and alkoxy groups; and R¿2? represents H, or one or more substituents selected from among the halogen atoms and the trifluoromethyl, alkyl, alkoxy, cycloalkyl, phenyl, cyano, acetyl, benzoyl, S-alkyl, alkyl-sulfonyl, carboxy and alkoxycarbonyl groups, or a group having formula NR¿3?R¿4, ?SO¿2?NR¿3?R¿4? or CONR¿3?R¿4?, in which R¿3? and R¿4 ?each represent H or an alkyl or cycloalkyl group or, together with the nitrogen atom, form a pyrrolidine, piperidine or morpholine ring. The invention also relates to the use of said compounds in therapeutics.
Composés de formule générale (I), dans laquelle n représente le nombre 1 ou 3, R1 représente soit H, soit un groupe cycloalkyle, cycloalkylalkyle, phénylalkyle, alcényle, alcynyle, X représente soit H soit un ou plusieurs substituants choisis parmi les atomes d'halogènes et les groupes trifluorométhyle, alkyles et alcoxy, R2 représente soit H, soit un ou plusieurs substituants choisis parmi les atomes d'halogènes, et les groupes trifluorométhyle, alkyles, alcoxy, cycloalkyles, phényle, cyano, acétyle, benzoyle, S-alkyles, alkyl-sulfonyles, carboxy et alcoxycarbonyles, soit un groupe de formule NR3R4, SO2NR3R4 ou CONR3R4, dans lesquelles R3 et R4 représentent chacun H ou un groupe alkyle ou cycloalkyle, ou forment, avec l'atome d'azote, un cycle pyrrolidine, pipéridine ou morpholine. Application en thérapeutique.
Dargazanli Gihad
Estenne-Bouhtou Genevieve
Medaisko Florence
Rakotoarisoa Nathalie
Kirby Eades Gale Baker
Sanofi-Aventis
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