C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/32 (2006.01) A61K 31/136 (2006.01) A61K 31/166 (2006.01) A61K 31/216 (2006.01) A61K 31/4184 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) A61P 25/06 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07C 213/00 (2006.01) C07C 219/32 (2006.01) C07C 231/00 (2006.01)
Patent
CA 2503075
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical neuron activity. More particularly, the invention provides derivatives of N- phenylanthranilic acid or 2-benzimidazolone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders and as neuroprotective agents.
L'invention concerne des composés, des compositions et des procédés qui sont utiles dans le traitement de maladies par la modulation du flux d'ions potassium dans les canaux potassiques dépendants d'une tension et/ou l'abaissement de l'activité des neurones corticaux. Particulièrement, l'invention présente des dérivés d'acide N-phénylanthranilique et de 2-benzimidazolone, des compositions et des méthodes utiles dans le traitement de troubles du système nerveux central périphérique et en tant qu'agents neuroprotecteurs.
Attali Bernard
Peretz Asher
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ramot At Tel-Aviv University Ltd.
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