C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/10 (2006.01) A61K 31/727 (2006.01) A61K 47/36 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2457719
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. Said glycosaminoglycan derivatives are endowed with antiangiogenic and heparanase- inhibiting acitivity ans are devoid of anticoagulant activity.
La présente invention concerne des dérivés de glycosaminoglycanes partiellement désulfatés, notamment l'héparine, et plus particulièrement, des composés représentés par la formule générale (I). Dans cette formule, les groupes U, R et R¿1? sont tels que décrits dans la description. Ces dérivés de glycosaminoglycanes, qui sont capables d'une activité anti-angiogène et d'une activité inhibitrice d'héparanase, sont dépourvus d'effets anticoagulants.
Casu Benito
Giannini Giuseppe
Naggi Annamaria
Penco Sergio
Pisano Claudio
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
Sigma-Tau Research Switzerland S.a.
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