Derivatives of penam-3-carboxylic acid and...

C - Chemistry – Metallurgy – 07 – D

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260/103, 260/113

C07D 499/70 (2006.01) C07D 499/00 (2006.01) C07D 501/20 (2006.01)

Patent

CA 1074295

ABSTRACT OF THE DISCLOSURE 6-Acylamino-penum-3carboxylic acids and 7-acylamino-3-cephem- 4-carboxylic acids in which the acyl group has the formula Image in which R1 is hydrogen, R2 is optionally substituted phenyl, thienyl or furyl or R1 and R2 together are optionally substituted cycloalkyl, n and m independently of one another represent 0 or 1 and B represents an optionally substituted 2,6-diozo- or 2,6-dithioxo-1,2,3,6-tetra- hydro-pyrimidyl, 2-thioxo-6-oxo-1,2,3,6-tetrahydropyrimidyl, 2,6-di- hydroxy- or 2,6-dimercapto-pyrimidyl, 2-mercapto-6-hydroxy-pyrimidyl, 2,6-diaminopyrimidyl, 2-amino-6-hydroxy-pyrimidyl or 2,6-dihalogeno- pyrimidyl radical, these radicals being bonded in the 4- or 5-position, and salts of these compounds, are manufactured by acylating correspon- ding 6-amino-penam or 7-amino-cephem compounds or corresonding phenylglyclamino compounds.

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