Derivatives of penem

Details Derivatives of penem Derivatives of penem

C - Chemistry, Metallurgy

07

D

260/111

C07D 519/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 499/88 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1339860

New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporin antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, .beta. -lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.

511536

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