Derivatives of phenyl-cycloalkanes and cycloalkenes

Details Derivatives of phenyl-cycloalkanes and cycloalkenes Derivatives of phenyl-cycloalkanes and cycloalkenes

C - Chemistry, Metallurgy

07

C

C07C 49/753 (2006.01) A61K 31/09 (2006.01) A61K 31/12 (2006.01) A61K 31/34 (2006.01) C07C 43/21 (2006.01) C07C 43/235 (2006.01) C07C 43/243 (2006.01) C07C 43/247 (2006.01) C07C 43/253 (2006.01) C07C 45/62 (2006.01) C07C 45/68 (2006.01) C07C 323/00 (2006.01) C07C 325/02 (2006.01) C07D 307/20 (2006.01)

Patent

CA 2079785

2079785 9115451 PCTABS00007 A compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is -CH3 or -CH2CH3 unsubstituted or substituted by 1 to 3 fluorines; X is O or S(O)s where s = 0 to 2; R2 is C4-C6 cyclic alkyl, optionally substituted by one to three methyl groups or one ethyl group; -CH2-cyclopentyl, -CH2-cyclopropyl, 3-tetrahydrofuranyl, C1-7 alkyl, CH3 or CH2CH3 substituted by one to three fluorines; -(CH2)nCOO(CH2)gCH3, or (CH2)nO(CH2)gCH3, wherein n is 2 to 4 and g is 0 to 2; R3 represents a moiety of formula (a) wherein R4 and R5 each represent hydrogen or R4 and R5 together represent a bond; B represents >C=O, >C=S or >CH-R6 wherein R6 represents H, OH, C1-6 alkoxy or C1-6 thioalkoxy; and m and r each independently represents zero or an integer in the range of 1 to 4 wherein m+r represents an integer in the range of from 2 to 4; with the proviso that when R1 is methyl, X is oxygen, R2 is methyl or cyclopenyl, R3 does not represent cyclopent-1,2-ene-3-one.

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