Derivatives of piperazine, process for their preparation and...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/08 (2006.01) A61K 31/495 (2006.01) C07D 295/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2541131

This invention relates to compounds of formula (I): (See formula I) wherein: - R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, - X represents a bond, an oxygen atom or a group selected from -(CH2)m-, -OCH2- and -NR5-, wherein m represents 1 or 2, and R5 is as defined in the description, - Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid, their uses and the preparation process and pharmaceutical compounds containing the.

La présente invention concerne des composés de formule (I) : (voir formule I) dans laquelle : - R1, R2, R3 et R4, identiques ou différents, représentent chacun un atome ou groupement choisi parmi H, halogène, alkyle, alkoxy, phényle et cyano, - X représente une liaison, un atome d'oxygène ou un groupement choisi parmi -(CH2)m-, -OCH2- et -NR5-, m représente 1 ou 2, R5 est tel que défini dans la description, - Y représente un atome d'oxygène ou un groupement choisi parmi NR7 et CHR8, où R7 et R8 sont tels que définis dans la description, Z représente un atome d'azote ou un groupement CH, - n représente 1 ou 2, - Ak représente une chaîne alkylène, - Ar représente un groupement aryle, ses isomères optiques, ainsi que ses sels d'addition à un acide pharmaceutiquement acceptable, leurs utilisations ainsi que le procédé de préparation et les compositions pharmaceutiques qui les comprennent.

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