Derivatives of pituitary posterior lobe hormones

Details Derivatives of pituitary posterior lobe hormones Derivatives of pituitary posterior lobe hormones

C - Chemistry, Metallurgy

07

K

C07K 7/16 (2006.01) A61K 38/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2085603

2085603 9200996 PCTABS00010 Derivatives of pituitary posterior lobe hormones, more precisely new vasotocin derivatives, are disclosed. The new vasotocin derivatives are comprised by formula (I), wherein A = Mpa or Hmp, B = D-Tyr, D-Tyr(Et), D-Phe, D-Phe(p-Et) or D-Trp, C = Thr, Val or Hgn, D = Cys or .alpha.-Abu, E = Pro or a peptide bond, F = (a), wherein m = 0-6, n = 0-6, L = H, C00H, CO-NH2 or CH2-OH, K = H, (b) or a D- or L-amino acid residue with the proviso that L is not H when A is Mpa, C is Thr or Val and D is Cys. Further, pharmaceutical compositions including the new vasotocin derivatives and being preferably in a form suitable for intravenous, intranasal or intraintestinal administration, are described. The compositions are especially intended for use in the therapeutic treatment of excessive uterus muscle contractions.

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