Derivatives of pneumococcal choline binding proteins for...

A - Human Necessities – 61 – K

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Details

A61K 39/09 (2006.01) A61K 39/40 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2325340

The present invention provides bacterial immunogenic agents for adminstration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species.

L'invention concerne des agents bactériens immunogènes destinés à être administrés à l'homme et à des animaux pour stimuler une réponse immune. L'invention concerne en particulier la vaccination d'espèces de mammifères présentant des polypeptides dérivés de pneumocoques qui comprennent une hélice alpha mais ne comprennent pas de région de liaison de choline qui stimule la production d'anticorps protégeant le sujet vacciné contre une infection aux espèces bactériennes pathogènes. Selon un autre aspect, l'invention concerne des anticorps contre ces protéines et les complexes de protéines, lesquels peuvent servir comme agents de diagnostic ou de protection contre des espèces bactériennes pathogènes.

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