Derivatives of pyrazolo[4,3-d]pyrimidin-7-ones which inhibit...

Details Derivatives of pyrazolo[4,3-d]pyrimidin-7-ones which inhibit... Derivatives of pyrazolo[4,3-d]pyrimidin-7-ones which inhibit...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 15/10 (2006.01) C07D 213/80 (2006.01) C07D 231/38 (2006.01) C07D 239/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2387357

Compounds of formula (I) wherein R1, R2, R4 and R13 are as defined or a pharmaceutically or veterinarily acceptable salt or polymorph thereof, or a pharmaceutically or veterinarily acceptable solvate or pro-drug thereof: are potent and selective inhibitors of type 5 cyclic guanosine 3', 5'-monophosphate phosphodiesterase (cGMP PDE5) and have utility in the treatment of, inter alia, male erectile dysfunction (MED) and female sexual dysfunction (FSD).

Cette invention concerne des composés représentés par la formule (I) dans laquelle R<1>, R<2>, R<4> et R<13> sont comme définis ou bien sont un sel acceptable au plan pharmaceutique ou vétérinaire, ou un polymorphe de ce sel, ou encore un solvat acceptable au plan pharmaceutique ou vétérinaire ou un promédicament de ce solvat; Ces composés sont des inhibiteurs puissants et sélectifs de type phosphodiestérase à 5 cyclique guanosine 3', 5'-monophosphate (cGMP PDE5) et conviennent notamment pour le traitement des troubles de l'érection chez l'homme et des dysfonctionnements sexuels chez la femme.

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