Derivatives of pyridinium thiomethyl cephalosporins, process...

Details Derivatives of pyridinium thiomethyl cephalosporins, process... Derivatives of pyridinium thiomethyl cephalosporins, process...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/36 (2006.01) C07D 213/70 (2006.01)

Patent

CA 1201432

PATENT APPLICATION entitled: New derivatives of pyridinium thiomethyl cephalosporins, process for preparing them and pharmaceutical compositions containing them in the names of: Bernard LABEEUW Ali SALHI assigned to: SANOFI ABSTRACT OF THE DISCLOSURE The present invention relates to cephalosporins of general formula: Image in which: - R1 is H or CH3, R2 is CH3, or R1 and R2 form a 1,3-propylene group, - R3 is lower alkyl, alkenyl, alkynyl or CH2COO alkyl, - R4 is H or OH, the S being bonded to the pyridine ring in 2 or 4 position, -A is H or cation or ester or hemiacetal which is easily hydrolysable, - and X is a derivative of a mineral or organic acid. The invention also relates to a process for preparing these new cephalosporins and to the drugs containing said cephalosporins.

415375

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