Derivatives of pyrido-benzothiazine with high anti-microbial...

Details Derivatives of pyrido-benzothiazine with high anti-microbial... Derivatives of pyrido-benzothiazine with high anti-microbial...

C - Chemistry, Metallurgy

07

D

167/180, 167/212

C07D 513/06 (2006.01) A61K 31/54 (2006.01) C07D 277/82 (2006.01) C07D 279/16 (2006.01)

Patent

CA 1340554

Pyrido-benzothiazine derivatives with high anti-microbial activity having the following general formula: Image wherein R is H or CH3; n is 0 or 1 or 2, and Y is Cl or F, Image wherein R1 is a C1-C6 alkyl or a C2-C6 alkenyl, or a phenyl lower alkyl, phenyl lower alkylcarbonyl, lower alkylcarbonyl or lower alkyloxycarbonyl, which may be substituted with halogen or hydroxy groups and their pharmaceutically acceptable salts with acids and bases. The present invention relates also to the processes for obtaining the compounds having the general formula (I). Such processes consist in synthesis routes using as starting products 3-chloro-4-fluoroaniline, or 2,3,4-trifluoroonitrobenzene.

474952

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