Derivatives of quinic acid and a process for their production

Details Derivatives of quinic acid and a process for their production Derivatives of quinic acid and a process for their production

C - Chemistry, Metallurgy

07

D

C07D 307/77 (2006.01) C07C 67/29 (2006.01) C07C 69/73 (2006.01) C07D 307/00 (2006.01)

Patent

CA 2101230

Abstract Derivatives of quinic acid and a process for their production 1-, 5-0-mono- and 3,4-0-bis-substituted deriva- tives of quinic acid are prepared by reacting a deriva- tive of a hydroxycinnamic acid of which the hydroxyl group(s) is/are protected with a quinic acid derivative to form an ester and the protective groups are then cleaved under controlled conditions of acidity and temperature. These conditions provide for regiospecifi- city of the esterification and enable any degradation of isomerization to be avoided. The process gives new quinides in high yields.

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