Derivatives of rifamycin

Details Derivatives of rifamycin Derivatives of rifamycin

C - Chemistry, Metallurgy

07

D

260/235.82

C07D 498/08 (2006.01) C07D 269/00 (2006.01)

Patent

CA 1055934

PROCESS FOR THE MANUFACTURE OF NEW ANTIBIOTICALLY ACTIVE COMPOUNDS Abstract of the Disclosure The invention refers to a process for the manufacture of selected 3-amino-rifamycin S and -SV derivatives, the amino group being of the aliphatic type, and more precisely being a 4R-1-piperazinyl- radical which is optionally substituted at the C-atoms by lower alkyl groups, and wherein R represents a hydrocarbon radical of the formula (III) Image , wherein Z1 - Z3 represent various hydrocarbon groups, including aromatic and cycloaliphatic groups, and Z' and Z" are optionally hydrogen or lower alkyl groups. These new compounds possess beyond a high general antibiotic action an especially high anti - tuberculosis effect, and are distinguished by a low toxicity.

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