Derivatives of saturated nitrogen heterocycles

Details Derivatives of saturated nitrogen heterocycles Derivatives of saturated nitrogen heterocycles

C - Chemistry, Metallurgy

07

D

C07D 211/46 (2006.01) A61K 31/445 (2006.01) C07D 211/22 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2089533

4-18973/A Derivatives of saturated nitrogen heterocycles Abstract of the Disclosure The invention relates to compound of formula I Image (I) wherein either R1 is a radical of formula Ia, -(CH2)n-O-NH2 (Ia) in which n is 0 or 1, and R2 is hydrogen, or R1 is hydrogen and R2 is a radical of formula Ib, -(CH2)p-O-NH2 (Ib) in which p is 1 or 2, and wherein R is C1-C2alkyl which is attached to one carbon atom of the central piperidine ring system, but not to the same carbon atom as R1 of formula Ia or as R2 of formula Ib; and m is 1 or 2, and salts thereof. The invention further relates to the preparation of these compounds, to intermediates obtained during their synthesis, to pharmaceutical compositions which contain them, and to the use of said compounds for the therapeutic treatment of the human or animal body and for the preparation ofpharmaceutical compositions. The compounds of formula I are inhibitors of orinthin decarboxylase.

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