C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.22
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/73 (2006.01)
Patent
CA 1340702
This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in Figure 6 from about +3 to about +185 fused to the amino acid sequence from about +351 to about +369. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in Figure 6 from about +3 to about +106 fused to the amino acid sequence from about +351 to about +369. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in Figure 6 from about +3 to about +185. This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
591702
Arthos James
Axel Richard
Maddon Paul J.
Sweet Raymond W.
Gowling Lafleur Henderson Llp
Smithkline Beckman Corporation
Smithkline Beecham Corporation
The Trustees Of Columbia University In The City Of New York
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