Derivatives of tachyplesin having inhibitory activity...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/08 (2006.01) A01N 37/18 (2006.01) A01N 63/02 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2179301

Certain specific derivatives of the 17-amino acid peptide tachyplesin has been found to have antimicrobial activity against plant pathogens. In a preferred embodiment, plant resistance to diseases caused by plant pathogens which are susceptible to these peptides is produced by inserting into the cells of a plant a gene whose expression causes production of one or more of the peptides of this invention in the plant in antimicrobial amounts.

On a constaté que certains dérivés spécifiques de la tachyplésine peptidique à 17 acides aminés ont une activité antimicrobienne contre les pathogènes végétaux. Dans un mode de réalisation préféré, la résistance du végétal aux maladies causées par des pathogènes végétaux sensibles à ces peptides est obtenue par insertion dans les cellules d'un végétal d'un gène dont l'expression induit la production d'un ou plusieurs peptides selon l'invention dans le végétal en doses antimicrobiennes.

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