C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/491, 260/556
C07C 233/16 (2006.01)
Patent
CA 1087207
ABSTRACT New derivatives of D-threo-1-phenyl-2-trifluoroacetamido-1,3-proanediol are described of the formula Image wherein R is CH3S- or CH3O2S- and R1 represents hydrogen or, when R repre sents CH3O2S-, even an acyl radical selected from the group consisting of aliphatic acids with 15-17 C atoms and aminoacetic acid. The new compounds are prepared by reacting a compound of formula Image wherein R has the above indicated meaning,with trifluoroeacetic acid or with a reactive derivative thereof and, in case esterifying the terminal hydroxy group with an aliphatic acid at 15-17C atoms or with glycine. The new compounds possess a wide spectrum antibiotic activity.
284228
Bella Davide D.
Cervato Giuseppe
Marca Gianfranco
Portelli Mario
Clesa S.p.a.
Ridout & Maybee Llp
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