Derivatives of thienylacetic acid amides and their...

C - Chemistry – Metallurgy – 07 – D

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C07D 333/24 (2006.01) C07D 333/28 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1244438

Abstract of the disclosure: Novel derivatives of thienylacetic acid amides of the general formula Image (I) in which the two nitrogens on the cyclohexane ring are trans- connected, the basic acetic acid amide radical is in position 2 or 3 of the thiophene nucleus, R is C1-C3 alkyl, R1 and R2 are independently C1-C3-alkyl or represent together with the nitrogen atom to which they are attached a pyrrolidine or piperidine ring and X and Y are independently hydrogen, chlorine or bromine in position 2 to 5 of the thiophene nucleus in depen- dence on the position of the basic acetic acid amide group, and their pharmaceutically acceptable acid addition salts are u-specific analgetics, which do not cause any physical dependence. Therefore, they are suitable for protracted treatment of pain conditions.

441249

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