Derivatives of thiophene-2-carboxylic acid and...

Details Derivatives of thiophene-2-carboxylic acid and... Derivatives of thiophene-2-carboxylic acid and...

C - Chemistry, Metallurgy

07

D

260/305

C07D 409/12 (2006.01) C07D 333/28 (2006.01) C07D 333/38 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1209576

ABSTRACT OF THE DISCLOSURE Derivatives of thiophene-2-carboxylic acid and the pharmaceutically acceptable acid or base addition salts there- of. The compounds of the invention have the structural formula Image (I), in which R is position 3 or 4 of the thiophene nucleus is hydro- gen, methyl, chlorine or bromine and R1 is hydrogen or C1-C4- alkyl. The compounds have a strong inhibitory effect on the thromboxane synthetase and are useful for the treatment of con- ditions such as inflammation, hypertension, thrombus, apoplexy, asthma, angina pectoris, ischemic heart diseases, ischemic con- ditions, migraine and vascular complications in connection with diabetes.

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