Derivatives of triterpenoid acids as inhibitors of...

Details Derivatives of triterpenoid acids as inhibitors of... Derivatives of triterpenoid acids as inhibitors of...

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01) A61K 31/70 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07H 15/18 (2006.01) C07H 15/203 (2006.01) C07H 15/207 (2006.01) C07H 15/24 (2006.01) C07H 15/256 (2006.01) C07H 17/04 (2006.01)

Patent

CA 2144166

Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these deriva- tives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/enndothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical for- mulations in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.

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