C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/22 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/34 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) C07C 233/47 (2006.01) C07C 233/49 (2006.01) C07C 255/29 (2006.01) C07C 255/60 (2006.01) C07C 323/41 (2006.01) C07D 209/18 (2006.01) C07D 213/56 (2006.01) C07D 307/54 (2006.01)
Patent
CA 2143636
A compound having structure (I), wherein A is X or Y, X is (a), Y is (b); R1, R2, R3, R4 and R5 are each independently hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group; and n is 0, 1, 2, or 3. Also provided are a compound containing a 2-valproenoic moiety, pharmaceutical compositions comprising these compounds, and methods of using them for the effective treatment of epilepsy and other neurological disorders.
Composé de la structure (I), dans laquelle A représente X ou Y, X représente (a), Y représente (b) , R1, R2, R3, R4 et R5 représentent chacun indépendamment hydrogène, un groupe alkyle C1-C6, un groupe aralkyle ou un groupe aryle, et n représente 0, 1, 2 ou 3. L'invention concerne également un composé contenant une fraction 2-valproénoïque, des compositions pharmaceutiques contenant ces composés, et des procédés d'utilisation de celles-ci dans le traitement efficace de l'épilepsie et d'autres troubles neurologiques.
Bialer Meir
Hadad Salim
Herzig Jacob
Lerner David
Shirvan Mitchell
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
Teva Pharmaceutical Industries Ltd.
Yissum Research Development Company Of The Hebrew University In
Yissum Research Development Company Of The Hebrew University Of
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