Derivatives of variolin b

Details Derivatives of variolin b Derivatives of variolin b

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2417629

The invention provides antitumour compounds of formula (I), wherein R1 is an aromatic substituent; R2 is hydrogen or a substituent when the dotted line is absent, or R2 is absent when the dotted line represents a bond to give a double bond between the nitrogen which bears R2 and the carbon which bears R3; R3 is an oxo group = O when the dotted line is absent or is a substituent when the dotted line represents a bond to give a double bond between the nitrogen bearing R2 and the carbon bearing R3; R4 is hydrogen or a substituent; and pharmaceutically acceptable salts thereof.

La présente invention concerne des composés antitumoraux repésentés par la formule générale (I), et certains de leurs sels phrmaceutiquement admis. Dans cette formule, R?1¿ est substituant aromatique. R?2¿ est hydrogène, ou substituant en l'absence de la liaison en pointillés, R?2¿ pouvant également être absent lorsque la liaison en pointillés aboutit à la formation d'une double liaison entre l'azote porteur du R?2¿ et le carbone porteur du R?3¿. R?3¿ est un groupe oxo = O en l'absence de la liaison en pointillés, ou substituant lorsque la liaison en pointillé aboutit à la formation d'une double liaison entre l'azote porteur du R?2¿ et le carbone porteur du R?3¿. R?4¿ est hydrogène ou substituant.

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