Derivatized calcitonins

Details Derivatized calcitonins Derivatized calcitonins

C - Chemistry, Metallurgy

07

K

C07K 14/585 (2006.01) A61K 38/23 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2153071

Derivatized calcitonin molecules, pharmaceutical compositions comprising derivatized calcitonins, and methods of reducing serum calcium in a patient using the derivatized calcitonins are disclosed. The molecules are characterized by a derivatized amino terminus formed by combining a calcitonin with a cyclic, polycyclic or heterocyclic moiety. Multimeric forms of the molecules are also disclosed.

Molécules de calcitonine dérivées, compositions pharmaceutiques comprenant les dérivés calcitonines, et procédé permettant de réduire le calcium sérique chez un patient au moyen des dérivés calcitonines. Ces molécules sont caractérisées par une extrémité amino-dérivée, formée par la combinaison d'une calcitonine avec une fraction cyclique, polycyclique ou hétérocyclique. Des formes multimères de ces molécules sont également décrites.

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