Derivatized dtpa complexes

Details Derivatized dtpa complexes Derivatized dtpa complexes

C - Chemistry, Metallurgy

07

F

167/101, 260/434

C07F 5/00 (2006.01) A61K 49/06 (2006.01) C07C 229/16 (2006.01) C07F 9/94 (2006.01) C07F 15/02 (2006.01)

Patent

CA 2020142

Compounds of the formula (see above formula) wherein: one of Z1 and Z2 is H, and the other is - (CH2)m-(C6H4)q-(O)k-(CH2)n-(C6H4)l-(O)r-R, wherein m and n, independently, are each 0-20, k, l, q and r are each, independently, 0 or 1, R is H, C1-C6-alkyl, OR1-substituted C1-C6-alkyl or CH2COOR1, where R1 is H, C1-C6-alkyl or benzyl; and X is, in each case, a hydrogen atom or a metal ion equivalent of an element of atomic number 21-29, 42, 44 or 57-83; with the provisos that: at least two of the substituents X represent a metal ion equivalent; when n and 1 each are 0, then k and r are not simultaneously 1; at least one of q and l is 1; -(O)r-R is not OH; and Z1, and Z2 are not -CH2-C6H9-O-CH2-COOCH2C6H5 or -CH2-C6H4-O- (CH2)5-COOCH2C6H5; as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR or X-ray imaging.

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