Derivatized polystyrene and other supports for spectroscopic...

C - Chemistry – Metallurgy – 08 – J

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18/1186, 150/8

C08J 7/12 (2006.01) C08J 7/02 (2006.01) G01N 33/545 (2006.01)

Patent

CA 1242862

TITLE: DERIVATIZED POLYSTYRENE AND OTHER POLYMER SUPPORTS FOR SPECTROSCOPIC STUDIES ABSTRACT Molded articles formed of polystyrene or other poly- mers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substi- tution of the primary substituent can be effected norm- ally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

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