Derived tyrosine hydroxylase gene expression system

Details Derived tyrosine hydroxylase gene expression system Derived tyrosine hydroxylase gene expression system

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2252529

The invention discloses a new system for gene expression. The system is based in particular on the use of derived sequences of the first intron of the tyrosine hydroxylase gene having transcription enhancing properties. The system is particularly useful in the production of proteins in vitro, ex vivo or in vivo, particularly in gene therapy applications.

La présente invention concerne un nouveau système pour l'expression de gènes. Le système de l'invention est basé notamment sur l'utilisation de séquences dérivées du premier intron du gène de la tyrosine hydroxylase possédant des propriétés d'enhancer de la transcription. Le système de l'invention est particulièrement avantageux pour la production de protéines in vitro, ex vivo ou in vivo, notamment dans des applications de thérapie génique.

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